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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770485699&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=bg-~b4C4dl-Dyi35nGlWhhELImTi6KHeMY43s-ftNRUmwtw5ddyT6nUKlzVgS~TuqdroLXpMbpoJAFXOd0HGXyYZk4ktDiBSGQIj3H2~IJISXgI~ebJXZDtAcc0pYoFUvc3gx4d5Rwh-aKNiyhn2xpgqja1nQrp2688S-1rJbDuGuGNrwd-B2r207CDxtGYEaetgY1U55kOke06ILcj9fy1av92JHSVgSVWb-gReTr1tG9NjS0oSr~kE6asfG1R~LzgV6pTn~wCOGxMpy2U3xuMFqfS-r-FXEXUextx8FRS4SaOqNswW93sXPfq3zO1F6ZlMGvGpxlQHOkqlVGMG5A__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770485699&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=KU7gtEj0Tb672J-WZypb2CGHnJRrYTumjfHmj-WeaU-oH6xbzzN8lcVKRTSox72pSf3l0QLq~6wAnLPmUVlzAtRIIF7xQ46zN2vin1eNOHn2WfafUm5GYe~YnZpHoopUu2igLWC59~57ajuNicDHQ5RoyFJm7NsfsTh8Fk3CskLITw6UjfNMpRaVrSk21fPjFYP0AsSR6irnfTEDUc8ka3Tj8S3QUOybmNNsR9M9N5054ufxGjIysm3Ys2MAX8hXH7rhAnQ7-uHAqbVm0b--~GQIxt~M0xJpV6kpnf4yu5~9rW0rPaXSLWXEe1Cv9XtXC-tJUtodzr5NaisG8~DgJg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger