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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774651987&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=lvX9l82BiPPPuYQiTVQth8Ym-tXIYAdoq5Ifan3hCIRwm~r7SPkdPVJtd4R1xVJmIebSyZ6pO41W0ZG3r9fVLe9o9UvEgTk9RVCNS8TA6Bpansh1A3kvlC7O~DyxLG0zQ2cf8jwfHh3NXd9YT6QijqHBFdJL4aBdKWw7iYETqftqQOgmOWb8xwR3U~9u85KU23LbIlR7qAacc8vRmPaFA0h1JxWO77-267-cXGa9RJ3FDPCK3GwW-iuR3sbZqiLteB-evbA7KoiY8sPFSod0PXP-2BG898IipxxESpf5wbb2Dp-BWOnSK98FDOzLnnZ6GjgSxWFn4nmfgm~f1k6kdg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774651987&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=QPg~ZeSIpyklXpZtPKapOvfY9q-lMGkdBbSoW-GocJ0y4KfCwT~QCaLByFa0aaLAXBCxLkF2h-q0InP8BW4yPtGoE029g4WRcCm1iwdiS0bFXCellyBlRtc5I~-koe2jHnKF7ulgEhzDtRYfhhoX6cFn-vtkXIKaqenPKv4TX5MCwd1l6oWnJ-2rAwfvOG0Ooy48fSg4iV1~r3L4k5ZP9QhJtfGmMv~xOtYEchex-dtWE1CwymQgy4dsMxhUtXRPT195GJB9JfATUCk2bxH7b1fLw6aqKgqQS5ksxvfNc0Mv4nxsiWFoeKO~IDyNAqe6-2acM4KeVjF98NSVYmanJA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger