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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086145&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=RYuKkcgCDVDFd9IMpf2Hxt5fnSG0PPhwdwlFl2LFsaD0Dq229ZbtlDZFXckYUs4BobHpN-0bkdObqd0ESuea9GhRwC-E0KKdWnmhQ8w2Bl-IQ0dwAeWJV-9HGX4Z~Vfw0IOS9f~QUyO-dn3i8xy1UPzv5nQHRJ9loWGCXGzNwyT9R8pLRKILevOiDZqlg5A3tWfq8qMv2Y~rBCZCgFmkvy6WgGYjG3OBrj8~ayss6jXo0gcCNz6R7MGXVabkvndFSK06Iy9cXAGjJn6Gqs1hzyLiEybvlkAK3t4xPf-a1Y9OzEkfFbIQT4CXYWkuxAAPm9pcHUFaZNFdXZi8Ic2kdg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086145&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=S15G7~~JYYTeVi4EOoF773r56PRibHRIcHKNreUlscTTDXE8Ba6ddzQcazjFjcbFWqcWOwln9iiP7dkn2iaL7hRG-8muJEi56qxieQlQEinC-WD7j3ZiNK7N263QkX8F2ERBciL-qryDbolnfkz30zbfQjRQbDhw8Hp2CQ7KYwrVcbDXSQa6pQlaVwdODHxwCtj~TjD4k3aChQVuCWWZ8W~X2AQlaqh8bCa~K8G0VrsDXGy-QEaQHW40M7hg3d0vX2h4R6~cCgPIvUeWufhzAcpo-HA~dMRrt4NSH-SzuguIpJyCAh-wGDmKjE~wHniwDIIx1WZprBKz98H56runWQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger