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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770474975&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mZ7o~oFYFxOM3SAj4oWccTRd2SawsAD1Ci8CWXuCTkishFelNzrX2UIwPI5h0wfQp5WSz5ai3DQZkcEkm-Tsj1CBoONBJNL-EOo0TAiveA-F-VmYI46xq1s5wF5FfAlXo-5XjCESEQ-FtPMhnEPnJIpqyQ8fQAT4d6-Pk4xGrAha4a5UYkJ1k2flaqRspZyS30RfZTBHfnO5Sxi61HvY3~z8vMyEqyk2CVWARMI6Gmb6JwLJJeSngvbdfnqmy96EnMzcoHgCvXkaeYVTFpg6CmqpyRfhUBdRc94SSGsksGm2zKi8tUMPgzyYpyjrEEPRi5D4I-ZItinnIu-GWuCbnQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770474975&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Hjm1OpAvw-z9lHtL1SAQ-Rggd28nl7h5DZW-tER~FIKhGVE6BOb7unSqZB5IJN-37unAFbebri8ydlc4TF48zbcJpa6RVu2ko-8lNQ3utJ6cjl-ioM2PSlDyrAMGf6p6egNxCYvUHuMrQ2t4jseACIR8nweW1OE19MfPvKM1rSNGY~CP~DyFEiblbz8wG~G-Usf5pD2IvpGAHSfI5pQ6TFtwqpPbzxmGP1sJ4czSjwmwns9ngZHFE3RsLlAshos2ZXROU-4O1hsp99qeFGGtfm8dqX3CablaOVW540PlLZrLpbwwwCDNyBB3VRgeSxjLhN6g29yW38A5FwsLrj1jGg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger