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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480178&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mnlrxpf5--0IGCAlSEQZgAU4m~ZVehViElGd~pU5GG5C5nSeeZLjT-AFvrfrKEMLDhx4WC42Qw-n7Rq9QSgEh43YHWzCdpLqi2p74v3TuI3JzOrJRsO0DM~wZUfgM9a-4trgnONZsiCHfTGytVrRZy4bsO6J7yr6VObQfr6eLWjF9qgxbCwjKLB6lPInOKoFaCBSH6yvxKcvX42CQnlwLZ5eDvkOJRMY0MpStFuqSnlfrCZosrEuJRpGh2oDTnoEn7MuizdMHOj59spzcOosJUMiPgGFcx9N7-~yjBrfJ7XgjMxPn7be~B4wSeH-OMMpp5qNzwVneok0ab23l0iQkQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480178&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=LiGG9if3NiuTEfr4PwEbkdV3J77JCftVwYLl0qZhu~dEBXxSCx44eO2eo~M0WebfTFyd9SYnfMp2aC1xZPikvdEj7ALtVGkAqOPNK0LS~1te5QbIP8rzogG9n~I3R4can2PIU6-grCjmvWPHrA-ZP-vRiFsIiabgOpqrbc3ZocQwN7b2gAbMNdw0-obbZSVcKiMSVVHYyV5MkgGHIWyWGgmH9FZctrK2zK8rF0mhpIha7zSCX2v4QK4gbFLcX0dTF-37JM9HGj4H9Y1oZeH9iMIROk1KX4lWjKL2LVWP3Bz7BTdoM1Ih8snscPW5NOkf08RUW5d89K~t4EFQ21Cc4w__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger