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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774657591&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=EXxWtGjUOVbGlhWEAXlxNB3z8zy7PcLjDw3qXipDjWhl3fpfdnjlaubrWFjSCJZiijJzlNu-uVHbXV5E-cjZN2HrDRJ9NBdA-3Kuu7ak6cQ-pnmvMbJMiKMKkixzHDTzm63qQaPxtiOW6ScR37oZf1QAYCUC9Z~BGdBpTv1JABT8DWq0uOHIO9Ub7x7cKfTILHB6-GEn8Q7rV37ThTroYdbRZf1Xf-ePhI6q3VW1wDC6drcYDzMYSkwG~AF7cxQEHcBxvDSrAa6jui5bkQBvc~9BKstuIWDTfJeaD8Esu-soAEjI0XXs59XZIqE92Dh6s5Rk~KPGraY9gXnFPKS5hg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774657591&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=i8N-RN8w-eMn5zgfz5fGoxW3~0mv8twYAG1pU5Z72b74fcfmq0reOYBu47CtiR7vsDt-Dmzb4nyFJFuxnZ6xJHTOkLWuXEhFsIAO8iCZ~-VHajoh5MAR7ykQS~0yHlO-1llBouzMVljsXBK4tLLBSZcJHK7TctHSvVRQe7QX0eqYQFFCJMPvr3xBoMQ0vOQ1Bwx4qeGKo2Q8eALrxvDEA7mFw6Tldg-9XUV96EynWY0FrS8PdyIBJvJ1GQQb6pv8t3C5BGG3AnMeJOdpu5zWRHif2oW6UxSVfPhEC7-wfLG64rXJEnR5nWebLTV761wZBJH6RwE5X3RAJH6oDQTEVg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger