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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480373&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mYBPNIg706yaRqu76HFjZlshs13qMYDl7duQ6M0nFJeL~9qrfcea-DI9zMxS8PIb1lopty6gISBmA4zV5ntQo-ocKwxrJWwUJJFxSfIyf~BMgHaeRHQN2udtExNcYpbJU9e-nk-xLT-~O75rDQ~gYg-iETCxaU7x05Iz259k5OlmL992k3hXWQaqTLRa-mWMRafuI~5sniPtH9~lKlLYfgrZV946eFthq7Usk7eeNazyv0vb6bC5T3d-PUSdrXxsDs-V34fConfvl2~YdZD~ZUchl4eGqaQjIWN1DHe-tOcWdW57WThvypU7Cvkn3P0TH~liVTgCMDwLqesEs8EKCA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480373&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=EOF0xUXK0kFUPiSe~4sUtSOkyFYPGmhhE4mlJQuEcppfvaC34-ZM4SkxXPCcrCkVtK93vTVmv6dY2G-hZsGDk8URNFLJ~iRjPTEa3cpJWIkQtbU-5pyqxm88tlAbn00Uo2EiD1bsIy95ohkdwLtArT~dSBA9wJHi~-RaQfEWjgPnUL3VB0cCaKdB2y10RpfMHLOf1J-okPahYE04E~VwY8YQeSA64RC96EspbxE9P0ac5GWBiPwlHcZMa2xkyqXstC7eFvvQOg5j1k7qNQDLFJaR5TLnyeoINAS2tGuQUJlqtpTxCbbhqxtaOHJFEIzx0qGpY7zvCYbhrfu4uPmPaQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger