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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774662997&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=anKcGjy6dvgs1DpW6uoZFrAODm6~Sw8HHW74y0Ibd15HsWYJcYTcIcEZQVKC7Lce2ngR2lX2X4gu-AsDl-AS5LGUiQ7KHxPwD9~8kShctTOdGTcq2EE7UfRJ1gsKvhahqmq5o1o3bVkdGVp88rBmSHgVzoC~To7OiVrWaR1omysA-7GAmcqcGdju4uUyRbpCBqfhfafke6UdFjHtGkrXcAqxOyvgqH3kUr3MFIZ7s6xYLGP8MuEIF6jXfFBi86FgxVYmvU~qEB9O8MFyGBN9bo81-YewE9SKOOfTF6I0lJHOggZXdXTBgzDt1OV1FyvUs~BINqWn-2T1uZkuUqs5mg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774662997&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=MWhoGq1xAD17Ta0JY6vWSg~qgnoW-Ecf639cdWHdRzR50luGmadsy5zHlrwjuqWYMkSSLq82u9Rz6Ph9R5kmYuaNaijc0DO5dAErWfWlAsOd4cbcYBJWPUmksjLEVMPbL0hcFG04b4F~Sd3h59XRkAr8awzmt~jvy1rf84PtVjzAyb2HWXMBoVyNBIqbeTfgIPX6q2nKt1sVrOPe2M1frMh37IjZie7oeHmbt2Pm0-522OSIUjI1aigFQ6pIhHl7eag53Ii0Y9QJ9qqAEejei2xY7CLyXmss4ZYRFeV~mkuWll03WOOu6JuHpQFSxxwCN9owTrBAtEYBesLfexIILg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger