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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774657752&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Eo3i5-kFAEX~M71UuthoRqQchCF-nfrTWoNA0b1oZE7ScW85pfLDcWDrqNH0LOcgCe2KyCTz9Qadrs3TT2exflR2UivcG8UsxejruVHTznw6XFzrYzX7NyjPcvvmEgCLRlWkK7d1n-VBbwovnY~~vojihZk7OpPBJvGf90rnqZAGCRO7G-3a5SO86KFzGTHAsAoibQw2aOy8-mAuD~CJMX8YaaZPdDqxeCgMf-RFH-lDAVJW39mFrx4wvWx5mJJcrPJhLEf0wtv4gyH6DAuRffTLU9H6r6FmNT8~B337aRlfQaDljxLlcKwSNgP5HMj59XvQFrP7Vm0RsYzVKKQ9iQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774657752&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=GWFelHUfWxil0SDP1JbZqiZrjTumiwMrcmb0v~QaYm6vlfPZpLHXdDbL5b0TtkgBdy~IGGoHb1sJdCN6xkmfXWTjcnt2rVDARNe94a~bo0xpfCkN~aBYsWhBgyoFb3WkcOPPk04c6SpopeGa8VoiXaCgr2-gsRKI3FAcuPPo~edvmiBGX-EvmG4HXYGVOs~Eh2gIpJfkDq05-wqKTkWv-kEUHizv4MJgPyH5auNy4lO9S~RpZBoBJ3idq2GpK0puQwREHJWrmQ7ElE5afsp1Gj1dzrO95vvFtS5nZsqnK5~53Dd-5WgqoiKX~5ApsjItbI3eHjXyCNvDJ0wrYQepxA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger