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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770485701&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=W6kZw35CljWcC710AGh1kK9EZbcSJXF4m4O7WjO1wiW8h5nQ4ruAmUtb3LHPPildB3H85j-ZgMUfl5d8v27QidDXu7YkcV2ytO5Wa2iagwer~0YdrHUDvuU1OSans222htQXOFAYyHibDgPjoRBPrKhrqj2KsfMw271x4uboMCLnhP5utaeUoF9U3LL4mGARU5nyzWwhh-1-C5Hun7wrburrrUbNXDPrZWRcv3NlABktda2wbljp99OF3fdSJb82OdLniqmC3gFQuy3NCrfbqKtit7SJrH-KNp~dAo99YHvcMWy4oFSzYm5WUvoeXnEOLnf7C~o1-SuyyeTasUJNfg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770485701&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Rvj2bdbj4IoZl~gyxAW1y-wPuS1ew8FTTps~FEzOiMxTMKPZQB7xxWAhpR5E1gX7iQKXrZilmRM7ped4axo73H3EiOOulskko8Jf5rLmGIESRMDTTCC7XJwdeDdLDNzc6X0whUXNq2OPTm1gm4TCtb19H5l8Mgusm1AI-9cg7aDsU3AgBLcsOa69tQoC8dGItaMSPHgAfAIDnCDFVCYcXI5f9aXnp4~44bCfchB2vaeankto856GULHSbG-Ly7IR0H9f22Ga382PkCVEtK0fIFs20JxmiWw0DCH8CBHsTC1~bDodzoc--R9xrrTHcGwPxGXobsN8qH2JpLVBnuUaAw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger