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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765089523&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=TMQGYHfF4F~p3bmWDwSdRdE6pPa~RRbAEHPMsdR~U~6R07isJCZC9xbFg99GTwlP~VYqu3NlXNu6HEOWjfoYELsUCIyUbV4NhzhsPojGaLRaRuT4Cqaljgu3jYO56rx7pMYLbf4COCv~bwZFfE4PZzAjIYWG4r3MFZd2MglXqUMT~SWmBKadZvyaSmonYz7FkjWSEttYlnSbRjVbbCKIOr7gInNKm78nZU-sDCESZ4iCxg2ItaJfBxhTXlnr8gvXb91zKz6Zaeml5oPErPumBA0qAHlB0RnG3s-59nhl4ab3ThVu9le~jclvXpyf4A5GSCGLNStudQ2F0s5KCiUOyA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765089523&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=ZNoFR4YVxFj4mb5kxNr7MpwXVsWojciLnexszmnetuKOybE0Xd5vGRj-Gy0y5g-v16KmqATBSxFUpC-tkbh-lrNeLa46GE1y8534KrGlr3PfWnhI8Ie66AE2t6ccgx3rZY9yZ4GHbysUK5-bzvZJAGmfxnClQbxoh0KXPChszw8cUvKxRiaxclslBx60id3nGn6UDZ1ZBFWYJidzO7chMY~ObB~w3eJpwiVNH0uzugdFyTxCUNgpQTwFFpprFjy-XsWgBGJegeONggjdF0nnSwfF1KVfao50CF2CpRFfJ8gRxQIR7NmyPrTu~9V~TWRv3puv7k3Ybva11J81-OPg0Q__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger