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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774663000&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=IKg80HhXll~JmdA9jfnwijZQtTgkVFn-VO-cZrWSKLhxE8y9bJ58X4Fod-iGSx1~a00n~z6jKIYeQp2MMgxymHuaQSzXryWLb6sNfNcjZE9eC~R1jr8soVHK5Xh3MxB8ni8oZtv0u30tqtaXABrd5AoOIqhnkMU2FBbhM-HpfRPO49pYFaXwmc0F1sbBTN1T5z1lkIJ5Z8fd6sij~295dC7N60RnUdtKYkOzeTFBDVjUS2iZ6khs4qPMDekhDHBAwfbDnN-IgNeJSFOBdSIdCibrorQIYEnb8KWqu6uI07ex~QZ9N164j7WuLRdbbXCW88VDfq4YeKGUMvu0TiUFww__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774663000&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=IEBi~c1-Nf7q0b5hS9wHJtG41nmgZm-ImhE4ypiOpgExgpTprMCvtlKAAAEs3mkO1KGAVYYUAmy9I0XlRDJoXpzF93rqvnXlidVQuRUyFT8b0kj7~Hjwmh2b-ZjfQ0MDm-nNSG-hsANiAhC~vfZ9OdJzb3ZB4-g6zhwHBxSdo9V68Zn~npdTVn-x8fUiSY5sHYdOSdNiL1EjzUOCHqgTA-O4amfcrC5FIJiz9KOcgP2UhQcErIPsWtTBLXRqUAfcyXRP3ZuRdj~8lrRxrt1La2k2Nyww3mqEzSOyhMkXh~OZgXzORAX9D9DcRuQYmY-ojlBGiREcBQbSuX-l8Y~FeA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger