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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774651909&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Jx7X-0YPOhSWu-kQrnlE~PWmQJ5PWUY7VDrZrzAFLMJT021dHPV3N1HmuCDjMjghN3-vM3Rjx-R2WlL0DtnMqfLC8EXQo-6pHLGnBTGJuSw1migxmeR3-Iwft~bZSFfvIw7AnhFPNw0JhG2bQPF~vPjFL0Uo46MGvJHAaY-SNxAWqw5W2l5h-UJfwVBgFqjvDfNRVeqR~6YtnoICaRfxheIQ1IQfQiHc5zGJMYcQ9AWOP-95r2KbjtlHCQs8wf8JrK8i7LHIC1RlfhN8IpA-k7hs-SFeYuQTEM1tU-Wee9IkV2DzEEZYj21JFLArRk10kOr~DUpxDYMLktX6vhFN2w__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774651909&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=doV5qKN-fPfWHsX9t88O2h381pzuAV-jPxaPU6UeDsdCyjqQrgk664W5VPnapm5mEkRJsa7tqqpxHLhhYHifXRUv~o30sEg2y3XbDm7YM8nmqEF7S6BN-gd4eAxeZSnzf7~h~OtXzE3FkMbqL2NTe3uh6MyDLZLSu64cM~tUy44ObupBIRI1WFV~oP4ne1FZXZCiF~ciit~oF3fHcOuQIV7EAYwYibQySzb2Vh9wBxs5qNDFqU-qvLlIkOfYhnKWtgNvU4IQMK130NwwA8HwjoQAB~RJjqKdJi04RQVASUoINcyHdhJ0geKXveSe6XjsLNLJLdGVIZznW84sdWNzvw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger