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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765092853&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=J9fKWMgEDmx~2p4l34X2GLoQWPxHh~-kjl0dspVOL4gqOq0wPLNhxBnRazobrh6yhHKdQpogUneYss~Jhm2aCAr0M-0BIX1tuPXZrJjzSHhw6wVzpPPM0eY6VxF~LQDjCQ8tK4eqUflicuugDxRwXb949ksSwQTEpxsz5ZgGez80McU6s5gN-06Aq46EXHRx3xc5N3df5bpsryCNRq7AZoUPW2P9UCngstbLj2OUpSxaWDf~HVRJwZKioX1HaD~y5hxon4yxjJjZyvK7WTFotYzRQk6vyO7PeDS8KNewu5AxJTajGJ3PliJmKYzr~XCixnKp50JaiYeb6feVUw8Dng__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765092853&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=BySm3kgUNybMZvEt3ndeYODL4FAOllpbIj60M-BLkAZoLhRL69g7mmczAT5TXYDpzkS-Fwg~cw5WYAZO7g7O5eJmQ-t7Ztpqpzon~XYmXEW0Kf1nkODpz3K4-87YlgOxOM5ZGJ0zfEwVUROQAdq4JtMxtRBuk7txhN6W6a8tbS3vAUF9JqXdynfHvWnNFe2ycz~3VGlQp2XVENZIFlghY~91s~qFljtDkk9LktXfu3LjGQ12Td5B7kjOhh0d4QiKNjiBNL1l~nv1E047uNSUsFa8TvzqGVozxem0ToRIwKrxLrWAQE8LlSKVEbL5~kfbwByHX4xNOmXogrNBZbQaWQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger