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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774652930&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=cKO4LgiSRl8BaGeW6ekT9inT60~xFqb7sL1SeXE38g7uJm-N~67KACyhkxbU-6bTHQNP3IG3UjKCrsHv7D2ti3z-XbnMdQKEcJLrx4wuyiomjdhjjY5-aavoQfSn6EyljxZGQY8~yd4tFYOr2rv~O9NOdZiyZLtNmsDL-5GsasF6ZZjJg~CIASZAbn6R5rEcjk-pDF5Px7nZ0HgRDikQvLvJ2bjFN2h3V5tCAvX8Fqbp-VmyG27tzA9l25R1TxZP7rxXK0BBoD97ok7zrkhuR5nyBP6D5vcZVuob7hyrwJrETmYVYjbwrrYDRPMFUqCjONuH-ApmCnRCaNVcsCSgww__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774652930&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=TrPJCLPfx-tYj8pw4TdBcUWzcC1Y2UShfczSrLiawXtA4aIOEu6MwSagzmGqIQmUMzQ2BePJcssh-dwxbF03QDSW~a~4EwXqHJzamUmBWX1LMsIM0t0oZvvElbGB1EXy3hd6gMm~URHcLsvM8G-MwoHukBiUF67nWupOd4NbJ0PnheFj-YgWivgpAc-4ocL4IhvvhDbEs06Y0emrlTeorMmT-BYrXdEEbZoyNHduBxjnoU0WMpubjBMZgwTHTRW6LNTEBrNtAPx2ZHA8qjZtB3FAFLjhZApBk3T-HYPb17Ogn~oxPqyDWMKWeWxegGBjLsZrJ-I3t5kDBd05qtVvew__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger