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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770474970&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=L-eMLfhNHTZ7RU754xsZTuSpcqDbJ5w1OQmncSNL6ahKTO2dBOEPv0eYrKrzlD9X-dndIHb1tZyl1UE22WhxYgin580H0KtYTqt2eNgbcmmMvTcCifJd3~9a~-GZ35Z3~xmMXqePFNDSsZqaWY8h~cdCrs~IVEC4gUv-e-3Dx6fgWFjz4xZqQgFeSlDtQiGM8Fta19IiDRV5zTI3rYTDqwwmNulJWtxGQBQiWM0TkfOR7gtX0LV8e4OiDhqNPsS2t76InkbNMdG6sVdio3CFB6M0NoimUbIQBaRRQYhJOl0t0tdAHv2nZYppnu4PqQVMDlmGdVoomuTprkBd5k62Uw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770474970&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=JGci33KeXyi4TLLI7X4Ym9FTxlJu-zqNuFwc75Kl8d40kIyZFnRANbqKiqfjWyFE0YrzgH0YaXiNwwOO7a5-yrlLMyTA0HHmLhT4KIIZ81giOzgmedtn3xQgyrkrvPWEKEBMJpeINMynQ7Kd0x~8S~~FvT2Fb46QoV2ogZgOA84SnV1kaUV6sLVL~agpJd2tXrXPIlXBDB4hW2Y-eaH72MmB7P2IQyYMILNq01nrbAme2kHJ6Qsd6FDmgmlmj4efkSvST00N5UfRqiiwvnVMLiSxRJzUmqnc0fWgO3w25TJIiuPvw0TpGiE2gmeRfLRnUxLzSv1oVl0Yd421Pk4wHg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger