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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774657548&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=H~quWmmWzypvaz4sHN-XSTOMtr7W1KEMNrBFunpTerfhW~YUmHUcRfIUAL5cKTNbVnGRHfJXFZBAcFaGJ-3N6Zm9yYtZYzjgGHTorXbZJQ42vDso8Y760dJeeqBcWbilFz4JuaQA6Cv74l3~vAMe~g5El-bXKJ-PcGY286y-l3AB6WdWW5TUPalfzHZkrwyloMDIRAiJBbqPcsZ7kixIZePXdZb~DYhQ-ts3LA-Vg1fUlTjBR~EUDGLTFTn7Yixr8O8vrzormKbgA-MOJlPaDtXqDfDy3ROj0Bw7XR7nE6MxExRh6zx-Q6MOdhfa4i5-j3DXW1dd2msowqGOlXq-gQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774657548&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Cy25LGbEorpgaJk8yVA14xF3i2zbykpiNwvNVkUb0Dx0WB57n6XVsLnPoglawcDuiXPtU-WI2AlAEHBmr8J0LePnnyfpeW0h4R1xuZ8F7VgzxdydOAdPIK6L~4OSHSFFf4nqgK4On1r9BY03fiUdGxaX1eIz4UA96Tc3-~N0nN3k2MZ8nyYjEhZi8sevSONIBzL4xOrxI9ZQwBRnfHxYtMTaZ3Ho41dXPGqNK0CbCRjzsaaKbCZRrL3C9I-JdWQJ3KXiG76D2YAgesEOSBA1WymIOLHWvT17WREDjd3DEnvYfVxj6d0~5NcN4c2bkanPuKq3PN3h3HDkqZ7FrZjeYQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger