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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765086841&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=cgvWz-1f1ZQXLbRQ464Q-qgyc2Av9nZoj-LZcI9vZfyWq2gjGkwxfxOM5dWVeF3wsl2QEv0psHMq~m23uyXv0undSuwApfNQHauXkFN9-tvGBkOv3c~j9adjTxypHF4TyuESUndvQXVEiuZVbFaN1LTYikIaKClblcBn6fyPgtAWNz67Ol0HCW3vxqe2jl75LX3eTZ9hPDMpEGxWTFnD8N9q0jxjR-hj9oVITjFj~6-6JfyikF8nltImN1bs1gHyKTIvcE0I14h3a10rO5hv2hhE5SJsRvDciqBpd0e5I59thTLYD1~EW0SBqnxZnNuoaMhU0RenO78drR3Qxeogng__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765086841&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=X5TdChWm60G3tnoaCbVEr6azRoJZgSba6kTIOfCUIJgCU5LAIbZDhNYx0k~KbA-AHcEe9gxQoV2brj~qcmcZuliJ-FJ5Ir3am8Aob-gl8sIUVw20OnmgDWPywl7cM0Y8heBfCOu5LFitHQpRINok7-RMVY00OymrhbwnPey9DBusYrciWtnlo4wP294QdP56zptjsP3GI~ZuS4saHmTw7GeR2X~ZbUbR~HaS2blfzw0s3j4zDKZURFcVifC554WaRC~E8mjkePOeYL78djVwsWJNK5MYxD6xhLFrwNnim2guDd~~E9iZtz3wczxLSerV1uCI07gl-20tmM8FHY3osg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger