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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770480158&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=jI9HABfh4Bdtv0mC8PE--3cjoIwHfItwYf7VS2SiPVaLbYpZI2DuSHy3sajZRA~nVmTxh5~Jj6SYDD8BSvecdFlaUlvIpMCJFCkxPHYgvOAr2jv1sW3SqHlALoGFM1QHkyqZY0QowqjSzHR9RWzcQQe2W50EQB3kgOF9Rl5k3~SR08SgAKFbl-MW2zrvBQ3JZKBKwaNC0cXDsVVR2LHJ-QRzv67q~CuuXJ9XJ-mDBSko3hw499PKdiq-CHREq7dFdCsp7vi~9wrLZwrsWCRYzOolZGFYj3dl-~MXGlnqbttbNu2DRguw4krFWAEo3VgDYYl6TpavuIJ05k4SwCWpHQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770480158&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=aqAdX5TO1kV~Nz3NsCGzfsqMoKBTc-J-2q2I3RcxyNJmNqNqHZLOe27ylONgaNBoJqGCBqU~QKD3hfyLqZj2uqkQDjSQofw~WtON3CY0YV0P9KlDNSbLlcvqV265LDi-6trf9~-L2IwSBXyDFcbxAiRGosx-h3eMF~1MA6Mx9Kh6GutoOcM~mLMFQTeOhb1iQcq7F-XDTqbaPcH7zaOB7R8gJnknTvx4gU3NHFw79SkxmwQ0Bf0PHh4fDKuAXvZNvK5fbuq1Wzn-UvvYwL0j-MqRw7SspWiSeEqQWHX1gt9-Zfhtw3zwM4rSw7iZYMDKTAKAmBs7MFvHj5oQoPYKtg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger