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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774658821&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mq7IrVtl5Fet~To0LxvP50MLCZFAL~WQuwL~J8mlkf0~nGmvHJrx6ZYi4jicFux8zfVwhEpAToa4Y2TG2jVdeXa5NdeS4G0ltK47ajs7b6dXe3dpmRIqDkrV-xflOyXS4jK~E7AcztevFQgSkzPV8DkvptOEprfWFQ6Fw4wwWoGcegmUo2TBnp0yS0FwGBXoH9e6F1yC-cr11ZvbiQ7oxEWX4IMNg~7uM0HkBWG~q-hYcqTeX5W7hdAtP2GPIiMQFNexq~XpXHS1xs0tHco24OGTcHNster8zQ7OXIFFEDRu47YAB4n0diraf4w-SHXa4soVdQDeEkvqAHpJ5VjrkA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774658821&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=RJMEktrL5F2KmMkXxvZ4nPIbB~f3JpnU0zpjtG8vi8r084MkGyAb5Tz-Ay~T0EIvoO9igvKykVtx9A-aKjKDiMDKNRph7ebBbdLOz0c6INMq1cruI77bt25ZJ~coq4XrBeSITTo4kUQKH4L1SxiZBc23nOqpzodrduEx6PCLrQaeDs~H~08Nlg79Ot6futo8cNd6SZl7lhuB7Sr1G5-wR~ZBQc0UYvjBXuw7fCJiKhSCSKbPllrWL9ynXadEIBw8-TsLfu9AoSsmkaZyvQPbcXxTj1DNdH0XxP40dYe9XZjxOTYDdX80u5ViLnPUSfvRYuZHXYCxkIloI8jX58-R2A__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger