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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774657753&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=g77nWteerQjNMMUEepoG0AM431UVfwC2Z3uGRLs4fCMmuzyeiSCcmB5TNRBvulAPymsazq~CcRApbIZEZymCSdL-Ie5dwCw7uevQ0nsOI69Re4x9zCQ8v6twc7uHwmMMJBX3UQzOkoC-Q~050IPdOHU25tImE3UvWIH2rl4QZ55BwJIPbUzw8sQiUyKDKd5LhOQLR5J6vZaH6FRsnziL7WBs7n7XPNTwOptXTnRsW30v2okpsfKgGBs0SNqrsYIdtSE5VGoe598fdAblC8mJ7avg-wIbUE3vyJlDZrhLO6G8A69hdzMVqFqjVME19UrL~h-dEbwReizORg1g9AD8Yg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774657753&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=KhNJ5RuQosrkPzOLy8Z4zVkkvBwKzWck9uf7cNE0ImMRLHaV0rPVT5qiVI7PMZMcIeYphb3a5hqE3NIXR81AN7SgovAEx~mv2BTHEtWXtvz9g6EYZBeUd4IYzgTJWkAjQC2kk5ZuCAHO0pY0DSPt6466epBKRy4zKx2n9o8guWrz2Czagc26i-E6KJ-vslqIiv30gjsxq2FXJF7A38kZpbXGMOPErxzg5A8T8dRfH9qU5kX-jdMIMjVn3HodDM9kXqTcooPLQs6xDMbAoN9eLj0hBL1hS9vP5ULmGWvTc33H9F3MRvQb77UjizEwp7F53llWLwYwSYPnM9MO4rGvHA__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger