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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1770485700&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=AVqvoHl1UIbhL4BOp17Qx6JcxfjtqI25stR75de0FMP-5B57nNRJcYFgsOjwF5svN2n-3c9n0jH9gR2cQr-y~zvnafmY5kO4p0LC-TfAvXTI3cXeHgy-dCvcXyKyzkqieEUXMpCJU8RvHBSLT10L-xX-prSQfU42eiHCetlRfYT80lYfSr7KXERvuWKvGabh8Udef1Od6o~U5COqGIs3dJxVTNyESWtCyiR~xNHZwkyq6P0cICjnDn7R2tzuOgxo2f58L3hr1W00i76DCFmhSPyEH44CRRgqFBt949Yz--AaDujBZ3FJxVJzAAx3bZnavMi-Af2pDbnkXZGoeVPVcg__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1770485700&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=L2vz3o-QMxw1rZn2gC28ZvN1frc0h6UXRMRm0l3uAHdaBab505PZiGRnEvX1CQ~4cuD7JSF1-59Lz9J0fFE0SaAVGRGfHlPza7twH1864PAGHe-ax-Gk~jAZwfI1IqftRc7NeWJHyyFHLZPa9bCgBWA1gnCUu7wH211E1sNBgikNH1TMo30mB5hd9spr7Hj4x0uEdC8e37u71uKLIhvS~PF7T1otRyIz32Pg4m64DFP8pAlx3AO5oQfVXjh8F5RsJrACpQw0OTpXWSjT5ykRqUEO~Gg2cst4C~kJRlgPskoV0MNqCBaVt9lpxZ90Ojzz-qvD70xr~4wpw6cb5xBYrg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger