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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1765089522&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Ux8~TT-t3da3eRCdZGopPSK5hRlPdoX9FkZjRvKG7pmGsj86kgL8n-0SfZUEh6DvDFJrQIdU2oheONzv7uSQvJ5K4zfGXL6PsrkNOsBETAIcWN9XQltAaTEYoDUflL96anpMBnHiOo62meF27SaUgU1WhSlF-7odXBNsAGFYIu77LVlDRwBp2pvFw31w-H3s~lxNhmHZrmwg~a7FrzxKdakZdKWZNRnQciro9-X~gxybTqWqlGbxwKkl6A0FKJsMdX0R6Ljol2ANqSxNW5Miwx67q15TkDELt18oxq10xo47pcRW1NcWgPZOz8FqG8drwWnj~BGqNNuJALUOsTg9IA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1765089522&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mNAjNt4tks6W5i2-EotRDkZ3JNoUuVDfFxVwX63HbM--suZVtmPhh8kcben~oFbYMfdbx01BZ-lc3onOWRAi0oxHWFLOCcmEtddf-T6uqiHOHNeAe1I-PusOuILPF33mqiWAm9BeorS-Iya4--b3b~O7sXth4udEnG5-cqOBw-H9UDWZANcTEIy~RBpQ3jBJ7~MI2DwYJcEemEgnkJuHtxD7W5QsH-bLLJXK1DEpx~68dwopNItYPpLdAnE0c6o8hretAsHZG8ID8AFafT9y2jF9iHjoa86yqDJBFEJP8njn6PNKjOGcT-OGWJK1hzr7QFyC6DQO0aWPGmPLX92vJw__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger